Department of OBGYN

Miguel Brieño-Enriquez , MD, PhD

  • Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Sciences

Education & Training

  • PhD in Cell Biology, Universidad Autonoma de Barcelona, 2007-2011
  • Masters in Cell Biology, Universidad Autonoma de Barcelona, 2006-2007
  • Masters in Biomedical Sciences, Universidad Autonoma de San Luis Potosi, 2005-2006
  • MD/Bachelors, Medical School, Universidad Autonoma de San Luis Potosi, 1996-2003

Representative Publications

1. Characterization of Telomeric Repeat-Containing RNA (TERRA) localization and protein interactions in Primordial Germ Cells of the mouse.

Brieño-Enríquez MA, Moak SL, Abud-Flores A, Cohen PE. Biol Reprod. 2018 Nov 13. doi: 10.1093/biolre/ioy243.

2. Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Brieño-Enríquez MA, Moak SL, Toledo M, Filter JJ, Gray S, Barbero JL, Cohen PE, Holloway JK. Cell Rep. 2016 Oct 18;17(4):977-986. doi: 10.1016/j.celrep.2016.09.059.

3. Double trouble in human aneuploidy.

Brieño-Enríquez MA, Cohen PE. Nat Genet. 2015 Jul;47(7):696-8. doi: 10.1038/ng.3344.

4. Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.

Brieño-Enríquez MA, García-López J, Cárdenas DB, Guibert S, Cleroux E, Děd L, Hourcade Jde D, Pěknicová J, Weber M, Del Mazo J. PLoS One. 2015 Apr 21;10(4):e0124296. doi: 10.1371/journal.pone.0124296. eCollection 2015. 

5. Gene expression is altered after bisphenol A exposure in human fetal oocytes in vitro.

Brieño-Enríquez MA, Reig-Viader R, Cabero L, Toran N, Martínez F, Roig I, Garcia Caldés M. Mol Hum Reprod. 2012 Apr;18(4):171-83. doi: 10.1093/molehr/gar074. Epub 2011 Nov 25.

6. Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development.

Brieño-Enríquez MA, Robles P, Camats-Tarruella N, García-Cruz R, Roig I, Cabero L, Martínez F, Caldés MG. Hum Reprod. 2011 Oct;26(10):2807-18. doi: 10.1093/humrep/der249. Epub 2011 Jul 26.

Link to publications


Clinical Interests/Research Interests

1. Development of systems to analyze human meiosis in vitro
2. Effects of endocrine disruptors in human meiotic prophase I
3. Transgenerational epigenetic effects, PGCs and non-coding RNAs
4. Regulation of cohesin removal mediated by NEK1 kinase
5. Protection of ovarian reserve and reproductive aging in mammals