| University of Pittsburgh |  |
UPMC | |
Health Sciences @ Pitt | |
School of Medicine | |
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 Department of Obstetrics, Gynecology & Reproductive Sciences |
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University of Pittsburgh Physicians
300 Halket Street Pittsburgh, PA 15213 Phone: 412-641-4220 Fax: 412-641-1133 |
| Faculty | |
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Gerald P. Schatten, Ph.D.
Director, Pittsburgh Development Ctr; Deputy Director, MWRIF Professor and Vice Chair, Department of Obstetrics, Gynecology & Reproductive Sci.; Director; Div of Develop & Regener Medicine; Professor of Cell Biology-Physiology; & Professor of Bioengineering University of Pittsburgh School of Medicine 204 Craft Avenue, B611 Magee Womens Research Institute Pittsburgh, PA 15213 Phone: 412-641-2403 Email: schattengp@upmc.edu Fax: , Faculty Research Interests |
| Education | |
| University of California, Berkeley A.B. 1971 Zoology University of California, Berkeley Ph.D. 1975 Cell Biology Rockefeller Foundation Fellowship Postdoc 1976 Reprod Biology German Cancer Research Center, Heidelberg Postdoc 1976 Cancer Biology Rockefeller Foundation Fellowship Postdoc 1977 Reprod Biology |
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| Publications | |
| 1. Hewitson, L., Dominko, T., Takahashi, D., Ramalho-Santos, J., Sutovsky, P., Fanton, J., Jacob, D., Monteith, D., Neuringer, M., Battaglia, D., Simerly, C., and G. Schatten. Births of ICSI monkeys: Unique Checkpoints during the First Cell Cycle of Fertilization. Nature Medicine, 5(4):431-433 (1999). 2. Luetjens, C.M., Payne, C., and G. Schatten. Non-random Chromosome Positioning in Human Sperm and Sex Chromosome Anomalies Following Intracytoplasmic Sperm Injection (ICSI). The Lancet, 353:1240 (1999). 3. Sutovsky, P., Moreno, R., Ramalho-Santos, J., and G. Schatten. Ubiquitin Tag for Sperm Mitochondria. Nature, 402, 371-372 (1999). 4. Chan, A.W.S., Dominko, T., Luetjens, C.M., Nueber, E., Martinovich, C., Hewitson, L., Simerly, C. and G. Schatten. Clonal Propagation of Primate Offspring by Embryo Splitting. Science, 287(5451) 317-31, (2000). 5. Moreno, R., Ramalho-Santos, J., Chan, E.K.L, Wessel, G.H. and Schatten, G. The golgi apparatus segregates from the lyposomal / acrosomal vesicle during rhesus spermiogenesis: structural alteration. Dev Biol, 219: 334-349, (2000). 6. Ramalho-Santos, J., Moreno, R.D., Sutovsky, P., Chan, A.W.S., Hewitson, L, Wessel, G.M., Simerly, C.R. and G. Schatten. SNAREs in Mammalian Sperm: Possible Membrane Fusion Events during Fertilization. Devel. Biol. 223; 54-69, (2000). 7. Chan, A.W.S., Chong, K.Y., Martinovich, C., Simerly, C., and G. SchattenTransgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes. Science 291:309-312 (2001). 8. Simerly, C., Dominko, T., Navara, C., Payne, C., Capuano, S., Gosman, G., Chong, K.Y., Compton, D., Hewitson, L., and Schatten, G. Molecular Correlates of Primate Nuclear Transfer Failures. Science 300:297 (2003). 9. Sutovsky, P., Moreno, R., Ramalho-Santos, J., and G. Schatten. Ubiquitin Tag for Sperm Mitochondria. Nature, 402, 371-372 (1999). 10. Chan, A.W.S., Dominko, T., Takahashi, D., Simerly, C. and G. Schatten. Clonal Propagation of Primates by Embryo Splitting. Science, 287(5451) 317-31, (2000). 11. Ramalho-Santos, J., Moreno, R.D., Sutovsky, P., Chan, A.W.S., Hewitson, L, Wessel, G.M., Simerly, C.R. and G. Schatten. SNAREs in Mammalian Sperm: Possible Membrane Fusion Events during Fertilization. Devel. Biol. 223; 54-69, (2000). 12. Ramalho-Santos, J., Sutovsky, P., Oko, R., Wessel, G.M., Simerly, C.R., Hewitson, L. and G. Schatten. ICSI Choreography: Fate of Sperm Structures After Monospermic ICSI and First Cell Cycle Implications. Hum Reprod 15:2610-20 (2000). 13. Sanchez-Partida, L.G., Dominko, T., Martinovich, C., McVay, B., Maginnnis, G., Fanton, J. and Schatten, G. Live Rhesus Offspring by Artificial Insemination using fresh sperm and cyropreserved sperm. Biol Reprod 63:1092-1097 (2000). 14. Sutovsky, P., Moreno, R.D., Ramalho-Santos, J., Dominko, T., Simerly, C., and G. Schatten. Ubiquitinated Sperm Mitochondria, Selective Proteolysis and the Regulation of Mitochondrial Inheritance in Mammalian Embryos. Biol Reprod 63:582-90 (2000). 15. Terada, Y., Simerly, C., Hewitson, L. and Schatten, G. Sperm aster formation and pronuclear decondensation during rabbit fertilization and development of a functional assay for human sperm. Biol. Reprod. 62: 557-563, (2000). 16. Terada, Y., Leutjens, C.M., Sutovksy, P., and G. Schatten. Atypical Decondensation of the Sperm Nucleus Delayed Replication of the male Genome an d Sex Chromosome positions following intacytoplasmic human sperm injection (ICSI) into golden hamster eggs: does ICSI itself introduce chromosomal abnormalities? Fertil Steril . 73:1092-8 (2000). 17. Cabot, R.A., Kuhholzer, B., Chan, A.W., Lai, L., Park, K.W., Chong, K.Y., Schatten, G.,Murphy, C.N., Abeydeera, L.R., Day, B.N., and Prather, R.S. Transgenic Pigs Produced Using In Vitro Matured Oocytes Infected With a Retroviral Vector. Anim Biotechnol. 12(2): 205-214 (2001). 18. Chan, A.W.S., Chong, K.Y., Martinovich, C., Simerly, C., and G. Schatten. Transgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes. Science 291:309-312 (2001). 19. Chan, A.W., Chong, K.Y., Takahashi, D., Martinovich, C., Duncan, N., Hewitson, L., Simerly, C., and Schatten, G. Reverse Transcription of Inserted DNA in a Monkey Gives Us ANDI: Response from Chan, et. al. Trends Pharmacol Sci May; 22(5):214-215 (2001). 20. Ramalho-Santos, J., Simerly C.R., Hewitson, L., Schatten, G. Acrosome Components after Intracytoplasmic Sperm Injection: The Decondensation Frontier. Fertility & Sterility, 76(1):196-197 (2001). 21. Ramalho-Santos, J., Wessel, G., Chan, E., and G. Schatten. Membrane Trafficking During Mammalian Acrosome Biogenesis. Exp. Cell Res., July 1;267(1):45-60 (2001). 22. Sutovsky, P., Moreno, R., Ramalho-Santos, J., Dominko, T., Thompson, W.E. and Schatten, G. A Putative, Ubiquitin-Dependent Mechanism for the Recognition and Elimination of Defective Spermatozoa in the Mammalian Epididymis. J Cell Sci. 114: 1665-1675 (2001). 23. Sutovsky, P., Terada, Y., and Schatten, G. Ubiquitin-Based Sperm Assay for the Diagnosis of Male Factor Infertility. Hum Reprod Feb;16(2):250-258 (2001). 24. Tengowski, M.W., Wassler, M.J., Shur, B.D., Schatten, G. Subcellular Localization of Beta 1, 4-Galactosyltransferase on Bull Sperm and its Function During Sperm-Egg Interactions. Mol Reprod Dev Feb;58(2):236-244 (2001). 25. Balczon, R., Simerly, C, Takahashi, D. and G. Schatten. Arrest of Cell Cycle Progression During First Interphase in Murine Zygotes Microinjected with Anti-PCM-1 Antibodies. Cell Motil Cyto. 52:183-195 (2002) 26. Hewitson, L., Martinovich, C., Simerly, C., Takahashi, D., and Schatten, G. Rhesus Offspring Produced By the Intracytoplasmic Injection of Testicular Sperm and Elongated Spermatids. Fertil Steril. 77: 794-801, (2002). 27. Moreno, R.D., Bustamante, E., Schatten, G. and Barros, C. Inhibition of mouse in vitro fertilization by an antibody against a unique 18-amino acid domain in the polysulfate-binding domain of proacrosin/acrosin. Fertil Steril. 77(4):812-7, (2002). 28. Moreno, R.D., Schatten, G., Ramalho-Santos, J. Golgi apparatus dynamics during mouse oocyte in vitro maturation: effect of the membrane trafficking inhibitor brefeldin A. Biol Reprod.66(5):1259-66, (2002). 29. Neuber, E., Chan, A.W.S., Dominko, T., Simerly, C., Schatten, G. Cell Allocation and Cell Death in IVF and ICSI Generated Blastocysts from Non-Human Primates. Fertility and Sterility 77(5): 1083-5, (2002). 30. Ramalho-Santos, J., Terada, Y., and G. Schatten. VAMP/synaptobrevin as an acrosomal marker for human sperm. Fertil Steril. 77:159-61, (2002). 31. Sutovsky, P., Neuber, E., and Schatten, G. Ubiquitin-Dependent Sperm Quality Control Mechanism Recognizes Spermatozoa With DNA Defects as Revealed By Dual Ubiquitin-TUNEL Assay. Molecular Reproduction and Development; 9999:1-8 (2002). 32. Terada Y, Nakamura SI, Hewitson L, Simerly C, Horiuchi T. Marukami T, Okamura K, and G. Schatten. Human sperm aster formation after intracytoplasmic sperm injection with rabbit and bovine eggs. Fertil Steril. 77: 1083-5, 2002 33. Schatten, Gerald P. Safeguarding ART. Fertility – Supplement to Nature Cell Biology and Nature Medicine. 19-22, October 2002 34. Ramalho-Santos, J., Schatten, G., Moreno, Ricardo D. Control of Membrane Fusion During Spermiogenesis and the Acrosome Reaction. Biol. Reprod. 67 (4) 1043-1051 (2002). 35. Neuber, E., Luetjens, C.M., Chan, A.W., and Schatten, G.P. Analysis of DNA Fragmentation of In Vitro Cultured Bovine Blastocysts Using TUNEL. Theriogenology. 57(9): 2193-2202 (2002). 36. Chan, A.W., Chong, K.Y., and Schatten, G.P. Transgenic Bovine Embryo Selection Using Green Fluorescent Protein. Methods in Mol Biol 183: 201-214 (2002). 37. Schatten, G.P. Commentary: Sperm mRNA – What Does Daddy Do? The Lancet 360: 742 (2002). 38. Schatten, G.P., Prather, R., and Wilmut, I. Cloning Claim Is Science Fiction, Not Science. Science 299:344 (2003). 39. Simerly, C., Dominko, T., Navara, C., Payne, C., Capuano, S., Gosman, G., Chong, K.Y., Compton, D., Hewitson, L., and Schatten, G. Molecular Correlates of Primate Nuclear Transfer Failures. Science 300:297 (2003). 40. Payne C, St. John JC, Ramalho-Santos J and Schatten G. LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte. Cell Motility and the Cytoskeleton. In press, 2003. 41. Payne C and Schatten G. Golgi dynamics during meiosis are distinct from mitosis and are coupled to endoplasmic reticulum dynamics until fertilization, Developmental Biology. In press, 2003. 42. Payne C, Rawe V, Ramalho-Santos J, Simerly C and Schatten G. Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization. Journal of Cell Science. 116(Pt 23): 4727-38 (2003) 43. Terada, Y., Nakamura, S., Morita, J., Simerly, C., Hewitson, L., Murakami, T., Yaegashi, N., Schatten, G., Okamura, K. Intracytoplasmic sperm injection: stiletto conception or a stab in the dark. Arch Androl. 49(3):169-77 (2003). 44. Terada, Y., Nakamura, S., Simerly, C., Hewitson, L., Murakami, T., Yaegashi, N., Okamura, K. Schatten, G. Centrosomal function assessment in human sperm using heterlogous ICSI with rabbit eggs: A new male factor infertility assay. Mol Repro and Devo. 67: 360-365 (2004). 45. Csoka, A.B., Cao, H., Sammak, P.J., Constantinescu, D., Schatten, G.P., and Hegele, R.A. Novel LMNA mutations in atypical Progeroid Syndromes. J Med Genetics (2004) 41(4):304-8. 46. Ramalho-Santos, J., Schatten, G. Presence of N-ethyl maleimide sensitive factor (NSF) on the acrosome of mammalian sperm.Arch Androl. 2004 50(3):163-8. 47. St. John, J.C. and Schatten, G. Paternal mitochondrial DNA transmission during non-human primate nuclear transfer. Genetics (2004). Jun; 167(2): 897-905. 48. Schatten, G., Donovan, P. Embryology: plane talk. Nature. 2004 Jul 15;430(6997):301-2. 49. Csoka, AB., English, SB., Simkevich, CP., Ginzinger, DG., Butte, AJ., Schatten, GP., Rothman, FG., Sedivy, JM. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell. 2004 Aug;3(4):235-43. 50. Rawe, VY, Ramalho-Santos, J., Payne, C., Chemes, HE., Schatten, GP. WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod. 2004 Nov;19(11):2594-2604. Epub 2004 Oct 7. 51. Simerly C, Navara C, Hyun SH, Lee BC, Kang SK, Capuano S, Gosman G, Dominko T, Chong KY, Compton D, Hwang WS, Schatten G. Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates:overcoming defects caused by meiotic spindle extraction. Dev.Biol.2004 Dec 15; 276 (2): 237-52. 52. Rawe VY, Payne C, Navara C, Schatten G. WAVE 1 intranuclear trafficking is essential for genomic and cytoskeletal dynamics during fertilization: cell-cycle-dependent shuttling between M-phase and interphase nuclei. Dev Biol.2004 Dec 15;276(2):253-67 53. Ben-Yehudah, A, Witchel SF, Hyun SH, Chaillet JR, Schatten GP. Can diabetes be cured by therapeutic cloning? Pediatr Diabetes. 2004;5, 2:79-87. 54. Rawe, VY, Payne, C, and Schatten, G. Profilin and actin-related proteins regulate microfilament dynamics during early mammalian embryogenesis. Hum Reprod. 2006 21(5): 1143-53. 55. Ahrens ET, Srinivas M, Capuano S, Simhan HN, Schatten GP. Magnetic resonance imaging of embryonic and fetal development in model systems.Methods Mol Med. 2006;124:87-101. 56. Moreno RD, Palomino J, Schatten G. Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis. Dev Biol. 2006; 293:218-27. 57. Sackett G, Ruppenthal G, Hewitson L, Simerly C, Schatten G. Neonatal behavior and infant cognitive development in rhesus macaques produced by assisted reproductive technologies. Dev Psychobiol. 2006 ;48(3):243-65. 58. St John JC, Amaral A, Bowles E, Oliveira JF, Lloyd R, Freitas M, Gray HL, Navara CS, Oliveira G, Schatten GP, Spikings E, Ramalho-Santos J. The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells. Methods Mol Biol. 2006;331:347-74. 59. Characterizing spermatogonial stem cells in adult rhesus macaques. Hermann, B, Suhkwani, M, Lin, CC, Sheng Y, Tomko, J, Rodriquez, M, Shuttleworth, J, McFarland, D, Hobbs, RM, Pandolfi, PP, Plant, TM, Schatten, G, Orwig, K.E. Stem Cells, 25(11):2695-704 (2007) 60. Pedigreed Primate Embryonic Stem Cells Express Homogeneous Familial Gene Profiles. Christopher S. Navara, Jocelyn D. Mich-Basso, Carrie J. Redinger, Ahmi Ben-Yehudah, Ethan Jacoby, Elizabeta Kovkarova-Naumovski, Meena Sukhwani, Kyle Orwig, Naftali Kaminski, Carlos A. Castro, Calvin R. Simerly, & Gerald Schatten. Stem Cells, 25(11):2695-2704 (2007) 61. Toppings M, Castro C, Mills P, Reinhart B, Schatten G, Ahrens E, Chaillet R, Trasler J. Profound phenotypic variation among mice deficient in the maintenance of genomic imprints. Human Reproduction, In press. (2008) |
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