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University of Pittsburgh Physicians
300 Halket Street
Pittsburgh, PA 15213
Phone: 412-641-4220
Fax: 412-641-1133
Faculty
 
Rajkovic.jpg Aleksandar Rajkovic , M.D., Ph.D.
Associate Professor, Department of Obstetrics, Gynecology and Reproductive Science. Division Chief, Genetics
204 Craft Avenue
Room A224 MWRIN
Pittsburgh, PA 15213
Phone: 412-641-8635
Email: rajkovic@upmc.edu
Faculty Research Interests
Personal Web Page
 
Research Interests
Our interests lie in basic sciences and translational research in the area of reproductive genetics. We are specifically interested in studying germ cell specific factors involved in the transcriptional regulation of mammalian gonadal development and meiosis, and their role in the genetics of male and female infertility. Moreover we are interested in the genetics of gonadal tumors such as ovarian cancer.
 
Education
UNDERGRADUATE:

1981- 1985 The Johns Hopkins University B.A. (05/1985) Chemistry
Baltimore, Maryland

GRADUATE:

1985-1992 Case Western Reserve University M.D. (05/1992) Medicine
Cleveland, Ohio

1985-1999 Case Western Reserve University Ph.D. (01/1991) Molecular Biology Cleveland, Ohio

POSTGRADUATE:

1997-1999 Baylor College of Medicine Medical Genetics Fellowship
Houston, Texas
 
Publications
Chlebowski RT, Kuller LH, Prentice RL, Stefanick ML, Manson JE, Gass M, Aragaki AK, Ockene JK, Lane DS, Sarto GE, Rajkovic A, Schenken R, Hendrix SL, Ravdin PM, Rohan TE, Yasmeen S, Anderson G; WHI Investigators.(2009) Breast cancer after use of estrogen plus progestin in postmenopausal women. N Engl J Med. Feb 5;360(6):573-87.

Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Lacroix A, Zheng W, Albanes D, Bamlet W, Berg CD, Berrino F, Bingham S, Buring JE, Bracci PM, Canzian F, Clavel-Chapelon F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Fox Jr JW, Gallinger S, Gaziano JM, Giovannucci EL, Goggins M, González CA, Hallmans G, Hankinson SE, Hassan M, Holly EA, Hunter DJ, Hutchinson A, Jackson R, Jacobs KB, Jenab M, Kaaks R, Klein AP, Kooperberg C, Kurtz RC, Li D, Lynch SM, Mandelson M, McWilliams RR, Mendelsohn JB, Michaud DS, Olson SH, Overvad K, Patel AV, Peeters PH, Rajkovic A, Riboli E, Risch HA, Shu XO, Thomas G, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hartge P, Hoover RN. (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. Sep;41(9):986-90.

Choi Y, Yuan D, Rajkovic A. (2008) Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression., Biol Reprod. 2008 Aug 27.
Choi Y, Ballow DJ, Xin Y, Rajkovic A. (2008) Lim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival, Biol Reprod. 2008 May 28.
Zhao H, Chen ZJ, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL, Rajkovic A. (2008) Transcription factor FIGLA is mutated in patients with premature ovarian failure, Am J Hum Genet. 2008 Jun;82(6):1342-8. Epub 2008 May 22.
Qin Y, Choi Y, Zhao H, Simpson J.L., Chen Z, Rajkovic A (2007) Nobox homeobox mutation causes premature ovarian failure, Am J Hum Genet., Sep;81(3):576-81.
Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. (2007) Microarray Analyses of Newborn Mouse Ovaries Lacking Nobox. Biol Reprod. Aug;77(2):312-9.
Choi Y, Rajkovic A. (2006) Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters. J Biol Chem. 2006 Nov 24;281(47):35747-56.
Pangas, S., Choi, Y., Ballow, D., Zhao Y., Westphal, H., Matzuk, M., Rajkovic, A. (2006) Oogenesis requires germ cell specific transcriptional regulators Sohlh1 and Lhx8, Proc. Natl. Acad. Sci. U.S.A, May 23;103(21):8090-5.
Ballow, D., Meistrich, M., Matzuk, M., Rajkovic, A., (2006) Sohlh1 is essential in spermatogonial differentiation. Developmental Biology, June 1;294(1):161-7.
Choi, Y., and Rajkovic, A., (2006) Genetics of early folliculogenesis. Cellular and Molecular Life Sciences, Mar;63(5):579-90.
Greenbaum, M.P., Yan, W., Wu, M.H., Lin, Y.N., Agno, J., Rajkovic, A., Matzuk, M.M. (2006) TEX14 is essential for intercellular bridge development and fertility in male mice, Proc. Natl. Acad. Sci. U.S.A, Mar 28;103(13):4982-7.
Pangas, S.A., and Rajkovic, A. (2006) Transcriptional regulation of early oogenesis: In search of Masters. Human Reproduction Update, Jan-Feb;12(1):65-76.
Rajkovic A., Pangas, S.A., Ballow, D., Suzumori, N., Matzuk M.M. (2004) Nobox regulates oocyte-specific gene expression in early folliculogenesis, Science, 305, 1157-1159.

 
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