Department of OBGYN

Charlene S. Dezzutti, PhD

  • Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences,
  • Associate Professor, Department of Infectious Diseases & Microbiology, Graduate School of Public Health

Education & Training

  • PhD Viral Immunology/Cell Biology, The Ohio State University, Columbus, OH, 1989
  • MS, Veterinary Pathobiology/Cell Biology, The Ohio State University, Columbus, OH, 1989
  • BS, Microbiology/Biochemistry, University of Pittsburgh, Pittsburgh, PA, 1986

Representative Publications

  • Murphy, K., Richardson, B.A., Dezzutti, C.S., Marrazzo, J., Hillier, S.L., Hendrix, C.W., Herold, B.C. Levels of Genital Tract Defensins and Cytokines Differ between HIV-Uninfected US and African Women. Am. J. Reprod. Immunol. 74(4):313-22, 2015. PMC4573314
  • Pellett Madan, R., Dezzutti, C.S., Rabe, L., Hillier, S.L., Marrazzo, J., McGowan, I., Richardson, B.A., Herold, B.C. Soluble immune mediators and vaginal bacteria impact innate genital mucosal antimicrobial activity in young women. Am. J. Reprod. Immunol. 74:323-32, 2015. PMC4573238
  • Bunge, K.E., Dezzutti, C.S., Rohan, L.C., Hendrix, C.W., Marzinke, M.A., Richardson-Harman, N., Moncla, B.J., Devlin, B., Meyn, L.A., Spiegel, H.M., Hillier, S.L. A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film. J. AIDS. 71:498-505, 2016. PMC5040830
  • Scott, Y. M., Park, S.Y., Dezzutti, C.S. Broadly neutralizing anti-HIV antibodies prevent HIV infection of mucosal tissue ex vivo. Antimicrob. Agents Chemother. 60:904-912, 2016. PMC4750682
  • Dezzutti, C.S., Else, L.E., Yandura, S.E., Shetler, C., Russo, J., Back, D.J., McGowan, I. Distinct pharmacodynamic activity of rilpivirine in ectocervical and colonic explant tissue. Antimicrob. Agents Chemother. 60:2765-2770, 2016. PMC4862523.
  • Dezzutti, C.S., Richardson- Harmon, N., Rohan, L.C., Marzinke, M.A., Hoesley, C.J., Panther, L., Johnson, S., Nuttall, J.P., Nel, A., Chen, B.A. on behalf of the MTN-013/IPM 026 protocol team. Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial. Medicine. 2016. 95:28(e4174). PMC4956805

For additional publications, please see PubMed Page.

Clinical Interests/Research Interests

While sexual transmission of HIV has been identified to be the primary route of viral spread, decades into the HIV epidemic, the fundamentals of HIV transmission remain poorly understood. Dr. Dezzutti’s laboratory strives to elucidate the early events and potential co-factors involved in HIV transmission.

Although oral drugs have been approved for HIV prevention, not everyone will want to be on daily medication. Therefore, defining prevention options continues. Dr. Dezzutti’s laboratory also conducts side-by-side comparative assessments of microbicide candidates – products used topically to prevent the sexual acquisition of HIV – that will be used in clinical trials. The majority of the work done in her lab relies upon the use of polarized mucosal tissue explants.

The Dezzutti laboratory focuses on mechanism of transmission, factors that influence transmission (such as hormones and sexually transmitted infections) and prevention of HIV transmission. Please visit Dr. Dezutti’s research page to learn more about the ongoing studies being conducted in the laboratory.